Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …
prospect of drug screening, disease modelling and the generation of tissue for renal …
[HTML][HTML] Cardioids reveal self-organizing principles of human cardiogenesis
P Hofbauer, SM Jahnel, N Papai, M Giesshammer… - Cell, 2021 - cell.com
Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …
human development and disease. With the notable exception of the human heart, lineage …
Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies
T cell bispecific antibodies (TCBs) are the focus of intense development for cancer
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Nonclinical testing has served as a foundation for evaluating potential risks and
effectiveness of investigational new drugs in humans. However, the current two‐dimensional …
effectiveness of investigational new drugs in humans. However, the current two‐dimensional …
Integrated multi-omics approaches to improve classification of chronic kidney disease
S Eddy, LH Mariani, M Kretzler - Nature Reviews Nephrology, 2020 - nature.com
Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
associated comorbidities and pattern of injury on biopsy. Even within a given classification …
[HTML][HTML] Cell maturation: Hallmarks, triggers, and manipulation
JR Alvarez-Dominguez, DA Melton - Cell, 2022 - cell.com
How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors
Current kidney organoids model development and diseases of the nephron but not the
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …
contiguous epithelial network of the kidney's collecting duct (CD) system. Here, we report the …
Biomanufacturing human tissues via organ building blocks
The construction of human organs on demand remains a tantalizing vision to solve the
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …
organ donor shortage. Yet, engineering tissues that recapitulate the cellular and …