Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

Protein-DNA interactions are critical for the successful functioning of all natural systems. The
key role in these interactions is played by processes of protein search for specific sites on …

Nucleosome is a histone–DNA complex known as the fundamental repeating unit of
chromatin. Up to 90% of eukaryotic DNA is wrapped around consecutive octamers made of …

The nucleosome repeat length (NRL) is an integral chromatin property important for its
biological functions. Recent experiments revealed several conflicting trends of the NRL …

Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/histone
deacetylase (HDAC) repressor complex (SHREC) and is known to repress transcription at …

The process of protein search for specific binding sites on DNA is fundamentally important
since it marks the beginning of all major biological processes. We present a theoretical …

After Ctr1-mediated cell uptake, copper (Cu) is transported by the cytoplasmic Cu chaperone
Atox1 to P1B type ATPases ATP7A and ATP7B in the Golgi network, for incorporation into …

The RNA polymerase II (Pol II) transcribes all mRNA genes in eukaryotes and is among the
most highly regulated enzymes in the cell. The classic model of mRNA gene regulation …

Abstract Heterochromatin protein 1 (HP1) participates in establishing and maintaining
heterochromatin via its histone-modification-dependent chromatin interactions. In recent …

Recent genome-wide experiments in different eukaryotic genomes provide an
unprecedented view of transcription factor (TF) binding locations and of nucleosome …