Obstetric complications (OCs) can induce major adverse conditions for early brain
development and predispose to mental disorders, including schizophrenia (SCZ). We …

Hidradenitis suppurativa (HS), also known as Verneuil's disease and acne inversa, is a
prevalent, debilitating, and understudied inflammatory skin disease. It is marked by repeated …

Objectives How inflammatory signalling contributes to osteoarthritis (OA) susceptibility is
undetermined. An allele encoding a hyperactive form of the Receptor Interacting Protein …

Genome-wide association studies (GWAS) have cataloged many significant associations
between genetic variants and complex traits. However, most of these findings have unclear …

The number of variants that have a non-zero effect on a trait (ie. polygenicity) is a
fundamental parameter in the study of the genetic architecture of a complex trait. Although …

Assessing the causal tissues of human traits and diseases is important for better interpreting
trait-associated genetic variants, understanding disease etiology, and improving treatment …

Scientifically interesting as well as practically important phenotypes often belong to the
realm of complex traits. To the extent that these traits are hereditary, they are usually 'highly …

Polycystic ovary syndrome (PCOS) is a highly heritable disorder, but only a small proportion
of the heritability can be accounted for by common genetic risk variants identified to date. It is …

Environmental factors and gene-environment interactions modify the variable expressivity,
progression, severity, and onset of some classic (monogenic) Mendelian-inherited genetic …

Alopecia areata (AA) is a highly prevalent autoimmune disease that attacks the hair follicle
and leads to hair loss that can range from small patches to complete loss of scalp and body …