Lymphatic pumping: mechanics, mechanisms and malfunction

JP Scallan, SD Zawieja… - The Journal of …, 2016 - Wiley Online Library
A combination of extrinsic (passive) and intrinsic (active) forces move lymph against a
hydrostatic pressure gradient in most regions of the body. The effectiveness of the lymph …

Cancer-associated secondary lymphoedema

SG Rockson, V Keeley, S Kilbreath, A Szuba… - Nature reviews Disease …, 2019 - nature.com
Lymphoedema is an oedematous condition with a specific and complex tissue biology. In
the clinical context of cancer, the pathogenesis of lymphoedema ensues most typically from …

The unresolved pathophysiology of lymphedema

SH Azhar, HY Lim, BK Tan, V Angeli - Frontiers in physiology, 2020 - frontiersin.org
Lymphedema is the clinical manifestation of impaired lymphatic transport. It remains an
under-recognized and under-documented clinical condition that still lacks a cure. Despite …

Advances in lymphedema

SG Rockson - Circulation research, 2021 - Am Heart Assoc
Lymphedema is a common, complex, and inexplicably underappreciated human disease.
Despite a history of relative neglect by health care providers and by governmental health …

Cardiac lymphatics in health and disease

E Brakenhielm, K Alitalo - Nature Reviews Cardiology, 2019 - nature.com
The lymphatic vasculature, which accompanies the blood vasculature in most organs, is
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …

Associations of variation in retinal thickness with visual acuity and anatomic outcomes in eyes with neovascular age-related macular degeneration lesions treated with …

RN Evans, BC Reeves, MG Maguire… - JAMA …, 2020 - jamanetwork.com
Importance When initiating anti–vascular endothelial growth factor (VEGF) treatment for
patients with neovascular age-related macular degeneration (nAMD), knowledge of …

Leukotriene B4 antagonism ameliorates experimental lymphedema

W Tian, SG Rockson, X Jiang, J Kim… - Science translational …, 2017 - science.org
Acquired lymphedema is a cancer sequela and a global health problem currently lacking
pharmacologic therapy. We have previously demonstrated that ketoprofen, an anti …

Inflammatory manifestations of lymphedema

CL Ly, RP Kataru, BJ Mehrara - International journal of molecular …, 2017 - mdpi.com
Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory
process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary …

Current concepts in the surgical management of lymphedema

TA Kung, MC Champaneria, JH Maki… - Plastic and …, 2017 - journals.lww.com
Lymphedema is an incurable disease caused by insufficient lymphatic drainage leading to
abnormal accumulation of interstitial fluid within the soft tissues. Although this condition may …

TGF‐β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation

JE Baik, HJ Park, RP Kataru, IL Savetsky… - Clinical and …, 2022 - Wiley Online Library
Background Secondary lymphedema is a common complication of cancer treatment, and
previous studies have shown that the expression of transforming growth factor‐beta 1 (TGF …