Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

The potential benefits of quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms

MC Chiang, TY Tsai, CJ Wang - International Journal of Molecular …, 2023 - mdpi.com
Neuroinflammation is a critical factor in developing and progressing numerous brain
diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation …

Role of endogenous lipopolysaccharides in neurological disorders

M Kalyan, AH Tousif, S Sonali, C Vichitra, T Sunanda… - Cells, 2022 - mdpi.com
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …

The Nrf2 pathway in ischemic stroke: a review

M Farina, LE Vieira, B Buttari, E Profumo, L Saso - Molecules, 2021 - mdpi.com
Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

New therapeutic approaches to and mechanisms of ginsenoside Rg1 against neurological diseases

Y Sun, Y Yang, S Liu, S Yang, C Chen, M Lin, Q Zeng… - Cells, 2022 - mdpi.com
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury …

Pharmacological and molecular insight on the cardioprotective role of apigenin

SD Thomas, NK Jha, SK Jha, B Sadek, S Ojha - Nutrients, 2023 - mdpi.com
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables.
It possesses a wide range of biological properties that exert antioxidant, anti-inflammatory …

[HTML][HTML] Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia/reperfusion injury

L Wang, Y Liu, X Zhang, Y Ye, X Xiong… - Frontiers in cellular …, 2022 - frontiersin.org
Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …

Neuroprotective strategies for ischemic stroke—future perspectives

M Haupt, ST Gerner, M Bähr, TR Doeppner - International journal of …, 2023 - mdpi.com
Ischemic stroke is the main cause of death and the most common cause of acquired physical
disability worldwide. Recent demographic changes increase the relevance of stroke and its …

Drug delivery challenges in brain disorders across the blood–brain barrier: novel methods and future considerations for improved therapy

A Achar, R Myers, C Ghosh - Biomedicines, 2021 - mdpi.com
Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

Stroke: Molecular mechanisms and therapies: Update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …