[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

MG Cox, TP Peacock, WT Harvey, J Hughes… - Nature Reviews …, 2023 - nature.com
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option …

A detailed overview of SARS-CoV-2 omicron: its sub-variants, mutations and pathophysiology, clinical characteristics, immunological landscape, immune escape, and …

S Chatterjee, M Bhattacharya, S Nag, K Dhama… - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has created significant concern for everyone. Recent data from
many worldwide reports suggest that most infections are caused by the Omicron variant and …

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation

DY Chen, CV Chin, D Kenney, AH Tavares, N Khan… - Nature, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …

Severity of Omicron (B. 1.1. 529) and Delta (B. 1.617. 2) SARS-CoV-2 infection among hospitalised adults: a prospective cohort study in Bristol, United Kingdom

C Hyams, R Challen, R Marlow, J Nguyen… - The Lancet Regional …, 2023 - thelancet.com
Background There is an urgent public health need to evaluate disease severity in adults
hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data …

[HTML][HTML] Mortality risk among patients hospitalized primarily for COVID-19 during the omicron and delta variant pandemic periods—United States, April 2020–June …

S Adjei - MMWR. Morbidity and mortality weekly report, 2022 - cdc.gov
Mortality Risk Among Patients Hospitalized Primarily for COVID-19 During the Omicron and
Delta Variant Pandemic Periods — United States, April 2020–June 2022 | MMWR Skip directly …

Clinical severity of SARS-CoV-2 Omicron BA. 4 and BA. 5 lineages compared to BA. 1 and Delta in South Africa

N Wolter, W Jassat, S Walaza, R Welch… - Nature …, 2022 - nature.com
Omicron lineages BA. 4 and BA. 5 drove a fifth wave of COVID-19 cases in South Africa.
Here, we use the presence/absence of the S-gene target as a proxy for SARS-CoV-2 …

Characterization of SARS-CoV-2 Omicron BA. 4 and BA. 5 isolates in rodents

R Uraki, PJ Halfmann, S Iida, S Yamayoshi… - Nature, 2022 - nature.com
The BA. 2 sublineage of the SARS-CoV-2 Omicron variant has become dominant in most
countries around the world; however, the prevalence of BA. 4 and BA. 5 is increasing rapidly …

Omicron-associated changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms in the United Kingdom

KD Vihta, KB Pouwels, TEA Peto… - Clinical Infectious …, 2023 - academic.oup.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta
variant has been replaced by the highly transmissible Omicron BA. 1 variant, and …