Limited endoproteolysis of inactive precursor proteins at sites marked by paired or multiple
basic amino acids is a widespread process by which biologically active peptides and …

Abstract Hypoxia‑ischemia (H/I) brain injury results in various degrees of damage to the
body, and the immature brain is particularly fragile to oxygen deprivation. Hypothermia and …

Proproteins and prohormones are the fundamental units from which bioactive proteins and
peptides as well as neuropeptides are derived by limited proteolysis within the secretory …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding
behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early …

Much work has been done to identify susceptibility genes in schizophrenia and bipolar
disorder. Several well established linkages have emerged in schizophrenia. Strongly …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family which interacts
with high-affinity protein kinase receptors (Trk) and the unselective p75NGFR receptor. The …

Neurotrophic factors are a family of growth factors that modulate cellular growth, survival,
and differentiation. For many decades, it has been generally believed that a lack of …

Substantial evidence indicates that brain-derived neurotrophic factor (BDNF) plays a crucial
role in synaptic plasticity. Long-lasting synaptic plasticity is restricted to active synapses and …