The brain-derived neurotrophic factor (BDNF) has been suggested to play a pivotal role in
the aetiology of affective disorders. In order to further clarify the impact of BDNF gene …

Defects in synaptic development and plasticity may lead to autism. Brain-derived
neurotrophic factor (BDNF) plays a critical role in synaptogenesis and synaptic plasticity …

The network hypothesis of depression proposes that mood disorders reflect problems in
information processing within particular neural networks. Antidepressants (AD), including …

The precursor of brain-derived neurotrophic factor (BDNF)(proBDNF) is enzymatically
cleaved, by either intracellular (furin/PC1) or extracellular proteases (tPA/plasmin/MMP), to …

Neurotrophins are established molecular mediators of neuronal plasticity in the adult brain.
We analyzed the impact of aging on brain-derived neurotrophic factor (BDNF) and nerve …

Post-translational modifications (PTMs) play important roles in regulating several human
diseases, like cancer, neurodegenerative disorders, and metabolic disorders. Investigating …

Initially, the function of the fat mass and obesity associated (Fto) gene seemed to be
primarily the regulation of the body weight. Here we show that loss of Fto results in a …

Background Neurotrophin receptors were initially identified in neural cells. They were
recently detected in some cancers in association with invasiveness, but the function of these …

Cholinergic nucleus basalis (NB) neurons provide the major cholinergic innervation to the
cortical mantle, are selectively vulnerable in late stage Alzheimer's disease (AD) and require …

The neurotrophin brain‐derived neurotrophic factor (BDNF) binds to two cell surface
receptors: TrkB receptors that promote neuronal survival and differentiation and p75NTR …