Background Silicosis is one of the most common occupational pulmonary fibrosis caused by
respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a …

Silicosis caused by inhalation of silica particles leads to more than ten thousand new
occupational exposure-related deaths yearly. Exacerbating this issue, there are currently …

Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,
and currently used drugs cannot reverse the disease progress. Worse still, there are still …

Silicosis is a global occupational disease characterized by lung dysfunction, pulmonary
inflammation, and fibrosis, for which there is a lack of effective drugs. Pirfenidone has been …

Macrophages play an important role in causing silicosis eventually becoming an irreversible
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …

Silicosis is a leading cause of occupational disease-related morbidity and mortality
worldwide, but the molecular basis underlying its development remains unclear. An …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung
disease. Whether extracellular vesicles are effective in treating IPF and what is the optimal …

With the rapid development of nanotechnology, the potential adverse health effects of
nanoparticles have been caught more attention and become global concerns. However, the …

Crystalline silica (CS) particles are ubiquitous in the environment, especially in occupational
conditions, and exposure to respirable CS causes silicosis. The initial response to CS is …

Silicosis is an irreversible and progressive fibrotic lung disease caused by massive
inhalation of crystalline silica dust at workplaces, affecting millions of industrial workers …