Therapeutic approach to Alzheimer's disease: current treatments and new perspectives

T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

Current state of Alzheimer's fluid biomarkers

JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease

K Hou, J Zhao, H Wang, B Li, K Li, X Shi, K Wan… - Nature …, 2020 - nature.com
Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the
treatment of Alzheimer's disease (AD), and gold nanoparticles have previously been …

Alzheimer's disease prevention: from risk factors to early intervention

M Crous-Bou, C Minguillón, N Gramunt… - Alzheimer's research & …, 2017 - Springer
Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a
healthcare burden of epidemic proportions for which there is currently no cure …

New insights into the pathogenesis of Alzheimer's disease

L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

State of the science on mild cognitive impairment (MCI)

ND Anderson - CNS spectrums, 2019 - cambridge.org
Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …

Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria

B Dubois, H Hampel, HH Feldman, P Scheltens… - Alzheimer's & …, 2016 - Elsevier
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Alzheimer's disease: experimental models and reality

E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Brain‐derived neurotrophic factor, depression, and physical activity: making the neuroplastic connection

C Phillips - Neural plasticity, 2017 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …