Considering the role of epidermal keratinocytes, they occupy more than 90% of the
epidermis, form a physical barrier, and also function as innate immune barrier. For example …

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a significant
negative impact on the quality of life of patients. To date, the therapeutic landscape for the …

Abstract Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36
cytokines are composed of three agonists (IL-36α, IL-36β, and IL-36γ) and two antagonists …

The skin plays a crucial role in maintaining hydration, preventing dehydration, and
protecting against harmful microorganisms. Skin injury can lead to inflammation and fluid …

The role of NLRP1 inflammasome activation and subsequent production of IL-1 family
cytokines in the development of atopic dermatitis (AD) is not clearly understood …

The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the
innate immune system, linking innate and adaptative immune responses. This complex …

Introduction Generalized pustular psoriasis (GPP) is a rare form of psoriasis (less of 1% of
cases). Currently, GPP is recognized as a clinical entity, distinguished from plaque psoriasis …

Our skin provides a physical and immunological barrier against dehydration and
environmental insults ranging from microbial attacks, toxins and UV irradiation to wounding …

Inflammasomes are cytoplasmic protein complexes that play a crucial role in protecting the
host against pathogenic and sterile stressors by initiating inflammation. Upon activation …

Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
receptor that senses organelle dysfunction induced by various stimuli, such as infectious …