The PI3K/Akt/mTOR pathway: a potential pharmacological target in COVID-19

MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global
health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian …

The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy

MR Khezri, R Varzandeh… - Cellular & Molecular …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate …

Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways

H Zalpoor, M Bakhtiyari, H Shapourian… - …, 2022 - Springer
Hesperetin, an aglycone metabolite of hesperidin with high bioavailability, recently gained
attention due to its anti-COVID-19 and anti-cancer properties. Multiple studies revealed that …

Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases

MH Rahman, HK Rana, S Peng, MG Kibria… - Computers in biology …, 2021 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) still tends to propagate and increase
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …

[HTML][HTML] SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K/AKT pathway

AA Al-Qahtani, I Pantazi, FS Alhamlan… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 infects through the respiratory route and triggers inflammatory
response by affecting multiple cell types including type II alveolar epithelial cells. SARS-CoV …

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

HM Al-Kuraishy, AI Al-Gareeb, WA Negm… - …, 2022 - Springer
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) has been
identified as the source of a world coronavirus pandemic in 2019. Covid-19 is considered a …

Targeting the PI3K/Akt/mTOR pathway: A therapeutic strategy in COVID-19 patients

R Abu-Eid, FJ Ward - Immunology letters, 2021 - Elsevier
Some COVID-19 patients suffer complications from anti-viral immune responses which can
lead to both a dangerous cytokine storm and development of blood-borne factors that render …

The potential role of COVID-19 in progression, chemo-resistance, and tumor recurrence of oral squamous cell carcinoma (OSCC)

A Norouzi, M Liaghat, M Bakhtiyari… - Oral Oncology, 2023 - Elsevier
Numerous studies have revealed that cancer patients are more likely to develop severe
Coronavirus disease-2019 (COVID-19), which can cause mortality, as well as cancer …

Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases

H Zalpoor, A Akbari, M Nabi-Afjadi - Human Cell, 2022 - Springer
Currently, the coronavirus disease 2019 (COVID-19) pandemic has become a serious
concern to the worldwide healthcare system. Severe acute respiratory syndrome …