Unveiling the connection: long-chain non-coding RNAs and critical signaling pathways in breast cancer

R Thapa, O Afzal, G Kumar, AA Bhat… - … -Research and Practice, 2023 - Elsevier
Breast cancer is a complex and diverse condition that disrupts multiple signaling pathways
essential for cell proliferation, survival, and differentiation. Recently, the significant …

MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

AA Bhat, O Afzal, M Afzal, G Gupta, R Thapa… - … -Research and Practice, 2023 - Elsevier
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …

The complex role of MEG3: An emerging long non-coding RNA in breast cancer

MS Hussain, AA Majami, H Ali, G Kumar… - … -Research and Practice, 2023 - Elsevier
MEG3, a significant long non-coding RNA (lncRNA), substantially functions in diverse
biological processes, particularly breast cancer (BC) development. Within the imprinting …

From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer

MS Hussain, ASA Altamimi, M Afzal, I Kazmi… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …

PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

MA Hakami, A Hazazi, FR Khan, O Abdulaziz… - … -Research and Practice, 2023 - Elsevier
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region …

[HTML][HTML] Kaempferol: Paving the path for advanced treatments in aging-related diseases

MS Hussain, ASA Altamimi, M Afzal, WH Almalki… - Experimental …, 2024 - Elsevier
Aging-related diseases (ARDs) are a major global health concern, and the development of
effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has …

Melatonin: a potential regulator of DNA methylation

K Linowiecka, AT Slominski, RJ Reiter, M Böhm… - Antioxidants, 2023 - mdpi.com
The pineal gland-derived indoleamine hormone, melatonin, regulates multiple cellular
processes, ranging from chronobiology, proliferation, apoptosis, and oxidative damage to …

Introduction to epigenetics

N Singla, R Thapa, R Kulshrestha, AA Bhat… - Targeting epigenetics in …, 2023 - Springer
Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …

Melatonin, a natural antioxidant therapy in spinal cord injury

L Xie, H Wu, X Huang, T Yu - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a sudden onset of disruption to the spinal neural tissue, leading to
loss of motor control and sensory function of the body. Oxidative stress is considered a …

Beyond the genome: lncRNAs as regulators of the PI3K/AKT pathway in lung cancer

WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Lung cancer is a prevalent and devastating disease, representing a significant global health
burden. Despite advancements in therapeutic strategies, the molecular mechanisms …