Immune cells undergo a series of differentiation steps following a lineage-tree structure
stemming from hematopoietic stem cells. During differentiation of immune cells in both …

As development varies greatly across the tree of life, it may seem difficult to suggest a model
that proposes a single mechanism for understanding collective cell behaviors and the …

While context-type-specific regulation of genes is largely determined by cis-regulatory
regions, attempts to identify cell-type specific eQTLs are complicated by the nested nature of …

In an era of Biology where modern imaging and sequencing technologies allow to study
almost any biological process at molecular levels, it is now possible to study the content …

Many intrinsic functional characteristics of cells and tissues shape their genome-wide
expression patterns. But what other factors might also modulate these patterns are not fully …

Precise determination of cellular identity and molecular phenotypes through advanced high-
throughput technologies is crucial for understanding intricate tissue functions, especially in …

Recent debates among biologists have highlighted problems with the traditional concept of
cell type, which is considered vague and subjective. Single-cell technologies reveal the …

The advent of CRISPR-Cas9 genome editing technologies has spurred the development of
large-scale cell lineage tracing systems. These techniques involve integrating synthetic DNA …

Zellen des Somas, insbesondere des Gehirns, bilden regionenspezifisch unterschiedlich
häufig genomische Variationen aus, was zu einem somatischen Mosaizismus führt. Dieses …

The skin is a complex vital organ composed of several layers. The middle layer, the dermis,
is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing …