D Ao, X He, W Hong, X Wei - MedComm, 2023 - Wiley Online Library
As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B. 1.1. 529) has quickly become the dominant type among the previous circulating variants worldwide …
W Ma, H Fu, F Jian, Y Cao, M Li - Nature Ecology & Evolution, 2023 - nature.com
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies and/or increased transmissibility. The recently emerged Omicron subvariants exhibit a …
D Focosi, S McConnell, DJ Sullivan… - Drug Resistance Updates, 2023 - Elsevier
The mutation rate of the Omicron sublineage has led to baseline resistance against all previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …
The evolution of SARS-Coronavirus-2 (SARS-CoV-2) has been characterized by the periodic emergence of highly divergent variants. One leading hypothesis suggests these …
L Cegolon, R Pol, O Simonetti, F Larese Filon… - Pharmaceuticals, 2023 - mdpi.com
Background. Several drugs which are easy to administer in outpatient settings have been authorized and endorsed for high-risk COVID-19 patients with mild–moderate disease to …
Summary Background Earlier Omicron subvariants including BA. 1, BA. 2, and BA. 5 emerged in waves, with a subvariant replacing the previous one every few months. More …
G Verkhivker, M Alshahrani, G Gupta - Viruses, 2023 - mdpi.com
Evolutionary and functional studies suggested that the emergence of the Omicron variants can be determined by multiple fitness trade-offs including the immune escape, binding …
B Saldivar-Espinoza, P Garcia-Segura… - International Journal of …, 2023 - mdpi.com
Mutation research is crucial for detecting and treating SARS-CoV-2 and developing vaccines. Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python …
S Xiao, M Alshahrani, G Gupta, P Tao… - Journal of Chemical …, 2023 - ACS Publications
The new generation of SARS-CoV-2 Omicron variants displayed a significant growth advantage and increased viral fitness by acquiring convergent mutations, suggesting that …