[HTML][HTML] In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2

M Shah, R Yamin, I Ahmad, G Wu, Z Jahangir… - Plos one, 2024 - journals.plos.org
Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is the causative agent of
COVID-19 pandemic, which has resulted in global fatalities since late December 2019 …

The effectiveness of novel oral antiviral treatment for non-hospitalized high-risk patients with COVID-19 during predominance of omicron XBB subvariants

CK Hsu, WH Hsu, BW Shiau, YW Tsai… - Expert Review of Anti …, 2024 - Taylor & Francis
Objectives This study investigated the association between nirmatrelvir plus ritonavir (NMV-
r) or molnupiravir and the outcomes of non-hospitalized high-risk patients with COVID-19 …

The importance of including Long COVID outcomes when developing novel treatments for acute COVID-19

C Connor, HA Taylor - The Journal of Infectious Diseases, 2024 - academic.oup.com
The ongoing COVID-19 pandemic continues to present surges in infections demonstrating
the persistent threat posed by COVID-19. Amidst efforts to develop effective treatments for …

SARS-CoV-2 Antiviral Prescribing Gaps Among Nonhospitalized High-Risk Adults

ME Levy, E Burrows, V Chilunda… - Clinical Infectious …, 2024 - academic.oup.com
Within a multistate clinical cohort, SARS-CoV-2 antiviral prescribing patterns were evaluated
from April 2022–June 2023 among nonhospitalized patients with SARS-CoV-2 with risk …

Two short approaches to the COVID-19 drug β-dN 4-hydroxycytidine and its prodrug molnupiravir

KE Persaud, RR Sahu, MC Neary, AR Kapdi… - Organic & …, 2024 - pubs.rsc.org
Molnupiravir, the prodrug for β-D-N4-hydroxycytidine (NHC), is marketed by Merck as
Lagevrio™ against mild–moderate COVID-19, under FDA emergency use authorization. It is …

[HTML][HTML] Real-world use of nirmatrelvir-ritonavir in COVID-19 outpatients during BQ. 1, BQ. 1.1., and XBB. 1.5 predominant omicron variants in three US health systems …

NR Aggarwal, LE Beaty, TD Bennett… - The Lancet Regional …, 2024 - thelancet.com
Summary Background Ritonavir-boosted Nirmatrelvir (NMV-r), a protease inhibitor with in
vitro activity against SARS-CoV-2, can reduce risk of progression to severe COVID-19 …

[HTML][HTML] Safety and Effectiveness of Molnupiravir in Japanese Patients with COVID-19: Final Report of Post-Marketing Surveillance in Japan

S Shinozaki, A Watanabe, M Kimata… - Infectious Diseases and …, 2024 - Springer
Introduction Molnupiravir is an orally available prodrug of N-hydroxycytidine that received
special approval for emergency treatment of coronavirus disease 2019 (COVID-19) in Japan …

[HTML][HTML] Perceived Risk for Severe COVID-19 and Oral Antiviral Use Among Antiviral-Eligible US Adults

K Penrose, A Srivastava, Y Shen… - Infectious Diseases and …, 2024 - Springer
Introduction Oral antiviral medications are important tools for preventing severe COVID-19
outcomes. However, their uptake remains low for reasons that are not entirely understood …

The Value of Ursodeoxycholic Acid and Mesenchymal Stem Cells in the Treatment of Severe COVID-19

Q Zheng, Y Li, G Sheng, L Li - Microorganisms, 2024 - mdpi.com
Objective: The objective of this study was to evaluate the therapeutic efficacy of
ursodeoxycholic acid (UDCA) and mesenchymal stem cells (MSCs) in patients with severe …

Physician characteristics associated with antiviral prescriptions for older adults with COVID-19 in Japan: an observational study

A Miyawaki, K Kitajima, A Iwata, D Sato, Y Tsugawa - BMJ open, 2024 - bmjopen.bmj.com
Objectives Although guidelines recommend antiviral therapy for outpatients with COVID-19
who are at high risk of progressing to severe conditions, such as older adults, many patients …