ABSTRACT Ribonuclease P (RNase P) is an ancient and essential endonuclease that
catalyses the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). The …

The skeleton affords a framework and structural support for vertebrates, while also
facilitating movement, protecting vital organs, and providing a reservoir of minerals and cells …

SHAPE-MaP is unique among RNA structure probing strategies in that it both measures
flexibility at single-nucleotide resolution and quantifies the uncertainties in these …

MRP RNA is an abundant, essential noncoding RNA whose functions have been proposed
in yeast but are incompletely understood in humans. Mutations in the genomic locus for …

Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains
genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic …

The growth of an individual is deeply influenced by the regulation of cell growth and division,
both of which also contribute to a wide variety of pathological conditions, including cancer …

In vivo UV crosslinking identified numerous preribosomal RNA (pre-rRNA) binding sites for
the large, highly conserved ribosome synthesis factor Rrp5. Intramolecular complementation …

Abstract Cartilage-hair hypoplasia (CHH), also known as metaphyseal chondrodysplasia
McKusick type (OMIM no. 250250), is an autosomal recessive, multi-systemic disease …

The human RNase MRP complex consists of a catalytic RNA and several protein
components. RNase MRP is a ubiquitously expressed eukaryotic endoribonuclease that …

We have identified a cell cycle delay in Saccharomyces cerevisiae RNase MRP mutants.
Mutants delay with large budded cells, dumbbell-shaped nuclei, and extended spindles …