Systems genetics approaches for understanding complex traits with relevance for human disease
Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …
complexity added by environmental factors. In medical research, systems genetics is a …
GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis
RL Ball, MA Bogue, H Liang, A Srivastava… - Genome …, 2024 - genome.cshlp.org
Hundreds of inbred mouse strains and intercross populations have been used to
characterize the function of genetic variants that contribute to disease. Thousands of disease …
characterize the function of genetic variants that contribute to disease. Thousands of disease …
Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis
Purpose Epistasis, the interaction between two or more genes, is integral to the study of
genetics and is present throughout nature. Yet, it is seldom fully explored as most …
genetics and is present throughout nature. Yet, it is seldom fully explored as most …
Rare and common variants associated with alcohol consumption identify a conserved molecular network
BS Leger, JJ Meredith, T Ideker… - Alcohol: Clinical and …, 2024 - Wiley Online Library
Background Genome‐wide association studies (GWAS) have identified hundreds of
common variants associated with alcohol consumption. In contrast, genetic studies of …
common variants associated with alcohol consumption. In contrast, genetic studies of …
Computational framework for statistical epistasis supports XOR penetrance function in a living system
Statistical epistasis has been studied extensively because of its potential to provide
evidence for genetic interactions for phenotypes, but there have been methodological …
evidence for genetic interactions for phenotypes, but there have been methodological …