Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

Potential therapeutic options for COVID-19: an update on current evidence

Z Niknam, A Jafari, A Golchin, F Danesh Pouya… - European journal of …, 2022 - Springer
Abstract SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19
pandemic and is a major public health concern nowadays. The rapid and global spread of …

Comprehensive health assessment 3 months after recovery from acute coronavirus disease 2019 (COVID-19)

B Van den Borst, JB Peters, M Brink… - Clinical Infectious …, 2021 - academic.oup.com
Background Long-term health sequelae of coronavirus disease 2019 (COVID-19) may be
multiple but have thus far not been systematically studied. Methods All patients discharged …

Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia

A Santa Cruz, A Mendes-Frias, AI Oliveira… - Frontiers in …, 2021 - frontiersin.org
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis …

[PDF][PDF] Large-scale multi-omic analysis of COVID-19 severity

KA Overmyer, E Shishkova, IJ Miller, J Balnis… - Cell systems, 2021 - cell.com
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

[HTML][HTML] NETosis and neutrophil extracellular traps in COVID-19: immunothrombosis and beyond

Y Zhu, X Chen, X Liu - Frontiers in immunology, 2022 - frontiersin.org
Infection with SARS-CoV-2, the causative agent of the Coronavirus disease 2019 (COVID-
19) pandemic, causes respiratory problems and multifaceted organ dysfunction. A crucial …

The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients

A Hariharan, AR Hakeem, S Radhakrishnan… - …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems
worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute …

Pathophysiology of COVID-19: mechanisms underlying disease severity and progression

MK Bohn, A Hall, L Sepiashvili, B Jung… - …, 2020 - journals.physiology.org
The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide
spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and …

[HTML][HTML] Severe COVID-19: NLRP3 inflammasome dysregulated

DF Van den Berg, AA Te Velde - Frontiers in immunology, 2020 - frontiersin.org
SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …