Aryl hydrocarbon receptor and its diverse ligands and functions: an exposome receptor

L Larigot, L Benoit, M Koual… - Annual Review of …, 2022 - annualreviews.org
The aryl hydrocarbon receptor (AhR) is a transcriptional factor that regulates multiple
functions following its activation by a variety of ligands, including xenobiotics, natural …

The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …

Nutritional therapy to modulate tryptophan metabolism and aryl hydrocarbon-receptor signaling activation in human diseases

M Ghiboub, CM Verburgt, B Sovran, MA Benninga… - Nutrients, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a nuclear protein which, upon association with
certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and …

COVID-19 is a multi-organ aggressor: epigenetic and clinical marks

MM Kgatle, IO Lawal, G Mashabela… - Frontiers in …, 2021 - frontiersin.org
The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both …

Sex differences in global metabolomic profiles of COVID-19 patients

RD Escarcega, P Honarpisheh, GD Colpo… - Cell death & …, 2022 - nature.com
Abstract Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms
ranging from asymptomatic disease to death. Although males are more susceptible to …

Increased kynurenine indicates a fatal course of COVID-19

H Mangge, M Herrmann, A Meinitzer, S Pailer, P Curcic… - Antioxidants, 2021 - mdpi.com
(1) Background: An inefficient immune response accompanied by an overwhelming
inflammatory reaction is involved in severe courses of COVID-19. Kynurenine (KYN) has …

Вольтамперометрический сенсор на основе аминокислотного комплекса меди (II) для определения энантиомеров триптофана

RA Zilberg, YB Teres, LR Zagitova… - Аналитика и …, 2021 - journals.urfu.ru
Разработан вольтамперометрический сенсор на основе композита
полиариленфталида (ПАФ) и графитированной сажи Carboblack C …

The microbiota/host immune system interaction in the nose to protect from COVID-19

A Di Stadio, C Costantini, G Renga, M Pariano, G Ricci… - Life, 2020 - mdpi.com
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that …

Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide

AAB Badawy - Bioscience Reports, 2020 - portlandpress.com
COVID-19 induces a proinflammatory environment that is stronger in patients requiring
intensive care. The cytokine components of this environment may determine efficacy or …

MAFB and MAF transcription factors as macrophage checkpoints for COVID-19 severity

MA Vega, M Simón-Fuentes… - Frontiers in …, 2020 - frontiersin.org
Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are
hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and …