Cancer and aging are two coupled developmental processes as reflected by the higher
incidence of cancer in the elderly human population group. Genetic mutations accumulate in …

Longevity, ie, the property of being long-lived, has its natural limitation in the aging process.
Longevity has a strong genetic component, as has become apparent from studies with a …

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the
genome of somatic cells. However, it is only recently that the necessary sophisticated …

The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

During the last years it was shown that the aging process is controlled by specific genes in a
large number of organisms (C. elegans, Drosophila, mouse or humans). To investigate …

With increasing age there is a cumulative increase in patients with ESRD. As Dr. Chris
Baylis has stated [1]:''With advancing age it gets more difficult to separate ''true''aging and …

Human progeroid syndromes are caused by mutations in single genes accelerating some
but not all features of normal aging. Most progeroid disorders are linked to defects in …

Background Despite the advances in our understanding of aging-associated behavioral
decline, relatively little is known about how aging affects neural circuits that regulate specific …

The presence of chemicals in our environment is a subject of intense interest owing to the
many potential adverse health effects to humans following exposure to these chemicals. The …

Genome‐wide and hypothesis‐based approaches to the study of ageing and longevity have
been dominated by genetic investigations. To identify essential mechanisms of a complex …