The Notch signalling pathway is a highly conserved developmental signalling pathway, with
vital roles in determining cell fate during embryonic development and tissue homeostasis …

Abstract 17β-estradiol controls post-natal mammary gland development and exerts its effects
through Estrogen Receptor ERα, a member of the nuclear receptor family. ERα is also …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

Aims Neoadjuvant chemotherapy (NAC) is the primary preoperative therapy for breast
cancer. The luminal subtype of breast cancer shows less NAC response than the basal …

Breast cancer (BC) is the most frequently diagnosed malignancy among women globally.
Although mouse models have been critical in advancing the knowledge of BC tumorigenesis …

During pregnancy, the maternal body undergoes a considerable transformation regarding
the anatomy, metabolism, and immune profile that, after delivery, allows for protection and …

Over the last two decades, many studies have demonstrated that the insulin-like growth
factor-1 (IGF-1) is involved in a number of patho-physiological processes, as well as in the …

Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast
cancer, the subtype triple-negative lacks expression of major differentiation markers, eg …

Background Studying the composition and developmental mechanisms in mammary gland
is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous …

The miR-200 family of microRNAs plays a significant role in inhibiting mammary tumor
growth and progression, and its members are being investigated as therapeutic targets …