[HTML][HTML] White blood cells and severe COVID-19: a Mendelian randomization study
Increasing evidence shows that white blood cells are associated with the risk of coronavirus
disease 2019 (COVID-19), but the direction and causality of this association are not clear. To …
disease 2019 (COVID-19), but the direction and causality of this association are not clear. To …
[HTML][HTML] Genome-wide association study identifies five risk loci for pernicious anemia
Pernicious anemia is a rare condition characterized by vitamin B12 deficiency anemia due
to lack of intrinsic factor, often caused by autoimmune gastritis. Patients with pernicious …
to lack of intrinsic factor, often caused by autoimmune gastritis. Patients with pernicious …
[HTML][HTML] Genome-wide association studies of COVID-19: Connecting the dots
LC Ferreira, CEM Gomes, JF Rodrigues-Neto… - Infection, Genetics and …, 2022 - Elsevier
Genome-wide association studies (GWASs) are a research approach used to identify
genetic variants associated with common diseases, like COVID-19. The lead genetic …
genetic variants associated with common diseases, like COVID-19. The lead genetic …
Addressing the challenge of biomedical data inequality: An artificial intelligence perspective
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …
healthcare and confer the predictive power essential to precision medicine. However, the …
Towards a global view of multiple sclerosis genetics
BM Jacobs, M Peter, G Giovannoni, AJ Noyce… - Nature Reviews …, 2022 - nature.com
Multiple sclerosis (MS) is a neuroimmunological disorder of the CNS with a strong heritable
component. The genetic architecture of MS susceptibility is well understood in populations of …
component. The genetic architecture of MS susceptibility is well understood in populations of …
[PDF][PDF] Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program
Summary Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and
non-coding disease-causing variants, has largely been applied to clinical diagnosis of …
non-coding disease-causing variants, has largely been applied to clinical diagnosis of …
[HTML][HTML] An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility
Background While genome-wide associations studies (GWAS) have successfully elucidated
the genetic architecture of complex human traits and diseases, understanding mechanisms …
the genetic architecture of complex human traits and diseases, understanding mechanisms …
[HTML][HTML] Canonical correlation analysis for multi-omics: Application to cross-cohort analysis
Integrative approaches that simultaneously model multi-omics data have gained increasing
popularity because they provide holistic system biology views of multiple or all components …
popularity because they provide holistic system biology views of multiple or all components …
[HTML][HTML] Alport syndrome: clinical spectrum and therapeutic advances
V De Gregorio, EB Caparali, A Shojaei, S Ricardo… - Kidney Medicine, 2023 - Elsevier
Alport syndrome is a hereditary disorder characterized by kidney disease, ocular
abnormalities, and sensorineural hearing loss. Work in understanding the cause of Alport …
abnormalities, and sensorineural hearing loss. Work in understanding the cause of Alport …
[HTML][HTML] Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
We explored ancestry-related differences in the genetic architecture of whole-blood gene
expression using whole-genome and RNA sequencing data from 2,733 African Americans …
expression using whole-genome and RNA sequencing data from 2,733 African Americans …