Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of
protease genes in the human genome, are secreted serine proteases with diverse …

Understanding complex functional mechanisms requires the global and parallel analysis of
different cellular processes. DNA microarrays have become synonymous with this kind of …

Background Our first predictor of protein disorder was published just over a decade ago in
the Proceedings of the IEEE International Conference on Neural Networks (Romero P …

Alternative splicing (AS) generates isoform diversity for cellular identity and homeostasis in
multicellular life. Although AS variation has been observed among single cells, little is …

Objectives: We sought to identify a novel gene for dilated cardiomyopathy (DCM).
Background: DCM is a heritable, genetically heterogeneous disorder that remains idiopathic …

Primary transcripts (precursor-mRNAs) with introns can undergo alternative splicing to
produce multiple transcripts from a single gene by differential use of splice sites, thereby …

It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …

Alternative splicing is the major source of proteome diversity in humans and thus is highly
relevant to disease and therapy. For example, recent work suggests that the long-sought …

Alternative splicing enhances proteome diversity and modulates cancer-associated proteins.
To identify tissue-and tumor-specific alternative splicing, we used the GeneChip Human …

Sequence-based methods for transcriptome characterization have typically relied on
generation of either serial analysis of gene expression tags or expressed sequence tags …