Neuroprotection by ozanimod following intracerebral hemorrhage in mice

F Wang, X Zhang, Y Liu, Z Li, R Wei… - Frontiers in Molecular …, 2022 - frontiersin.org
The destruction of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) is
associated with poor prognosis. Modulation of sphingosine 1-phosphate receptor (S1PR) …

Tissue Compliance and Intracranial Pressure Responses to Large Intracerebral Hemorrhage in Young and Aged Spontaneously Hypertensive Rats

CM Wilkinson, ACJ Kalisvaart, TFC Kung… - …, 2024 - Am Heart Assoc
BACKGROUND: After a large intracerebral hemorrhage (ICH), the hematoma and swelling
cause intracranial pressure (ICP) to increase, sometimes causing brain herniation and …

An ambiguous role for fever in worsening outcome after intracerebral hemorrhage

LJ Liddle, CA Dirks, M Almekhlafi… - Translational Stroke …, 2023 - Springer
Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leaves most
survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH …

Zhilong Huoxue Tongyu Capsules Ameliorate Early Brain Inflammatory Injury Induced by Intracerebral Hemorrhage via Inhibition of Canonical NFкβ Signalling …

M Mazhar, G Yang, L Mao, P Liang, R Tan… - Frontiers in …, 2022 - frontiersin.org
Background: Intracerebral hemorrhage (ICH) is a debilitating and fatal condition with
continuously rising incidence globally, without effective treatment available. Zhilong Huoxue …

A pilot systematic review and meta-analysis of neuroprotective studies in female rodent models of ischemic stroke

ML Gunderson, S Heer, AC Klahr - Translational Stroke Research, 2024 - Springer
Most ischemic stroke (IS) patients go untreated due to limited treatment windows, restrictive
eligibility criteria, and poor availability of current clinical therapies. Neuroprotective …

Intracranial pressure dysfunction following severe intracerebral hemorrhage in middle-aged rats

ACJ Kalisvaart, AH Abrahart, AT Coney, S Gu… - Translational Stroke …, 2023 - Springer
Rising intracranial pressure (ICP) aggravates secondary injury and heightens risk of death
following intracerebral hemorrhage (ICH). Long-recognized compensatory mechanisms that …

Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier …

L Gao, L Peng, P Sherchan, H Tang, Y Liu… - Fluids and Barriers of …, 2023 - Springer
Backgroud The frequencies of morbidity and impairment associated with spontaneous
intracerebral haemorrhage (ICH) are comparatively high. Blood-brain barrier (BBB) integrity …

Targeting focal ischemic and hemorrhagic stroke neuroprotection: Current prospects for local hypothermia

LJ Liddle, ACJ Kalisvaart, AH Abrahart… - Journal of …, 2022 - Wiley Online Library
Therapeutic hypothermia (TH) has applications dating back millennia. In modern history,
however, TH saw its importation into medical practice where investigations have …

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats

TFC Kung, CM Wilkinson, CA Dirks, GC Jickling… - PLoS …, 2021 - journals.plos.org
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema
and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks …

Role of eryptosis in hemorrhagic stroke

M Fang, F Xia, Y Chen, Y Shen, L Ma, C You… - Frontiers in Molecular …, 2022 - frontiersin.org
Erythrocytes undergo certain morphological changes resembling apoptosis during
senescence or in an abnormal state/site, which is termed eryptosis. This process is …