A 49-residue protein, echistatin, which inhibits platelet aggregation, was purified from the
venom of the saw-scaled viper Echis carinatus. The purification procedure included gel …

Summary lntegrin alI& (platelet GPllb-llla) binds fibrinogen via recognition sequences such
as Arg-Gly-Asp (RGD). Fibrinogen binding requires agonist activation of platelets, whereas …

Recent studies suggest that platelet stimulation leads to the induction of specific fibrinogen
receptors, which have been identified as the platelet membrane glycoprotein IIb-IIIa …

It has been suggested that fibrinogen (fg) or its physiological derivatives influence the
motility and growth of endothelial cells (ECs), but direct support for this concept is still …

Thrombospondin (TSP), the major alpha-granule protein of human platelets, binds to the
activated platelet surface upon platelet stimulation. TSP has hemagglutinating (lectin-like) …

Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A
alpha-chain. Although RGDS-containing peptides inhibit fibrinogen binding to stimulated …

Platelet membrane GPIIbIIIa is a member of the family receptors named integrins that
recognize RGD sequences in their ligands. GPIIbIIIa interacts with at least three different …

Synthetic peptides corresponding to the extreme COOH terminus of the gamma chain of
fibrinogen gamma 400-411,(400) HHLGGAKQAGDV (411), have been used to analyze …

Synthetic peptides corresponding to the carboxyl terminus of the fibrinogen gamma chain
inhibit the binding of fibrinogen, fibronectin, and von Willebrand factor to platelets, yet the …

Human umbilical vein endothelial cells (ECs) have been shown to attach to a substratum of
fibrinogen (fg). Later, ECs undergo spreading, organization of thick microfilament bundles of …