[HTML][HTML] Artificial intelligence in COVID-19 drug repurposing
Drug repurposing or repositioning is a technique whereby existing drugs are used to treat
emerging and challenging diseases, including COVID-19. Drug repurposing has become a …
emerging and challenging diseases, including COVID-19. Drug repurposing has become a …
[HTML][HTML] Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial
Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus
disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine …
disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine …
Reversed-engineered human alveolar lung-on-a-chip model
D Huang, T Liu, J Liao, S Maharjan… - Proceedings of the …, 2021 - National Acad Sciences
Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …
[HTML][HTML] In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication
A novel coronavirus, named SARS-CoV-2, emerged in 2019 in China and rapidly spread
worldwide. As no approved therapeutics exists to treat COVID-19, the disease associated to …
worldwide. As no approved therapeutics exists to treat COVID-19, the disease associated to …
[HTML][HTML] Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta …
Background Hydroxychloroquine or chloroquine with or without azithromycin have been
widely promoted to treat coronavirus disease 2019 (COVID-19) following early in vitro …
widely promoted to treat coronavirus disease 2019 (COVID-19) following early in vitro …
[HTML][HTML] A comprehensive review of viral characteristics, transmission, pathophysiology, immune response, and management of SARS-CoV-2 and COVID-19 as a …
COVID-19 emerged from China in December 2019 and during 2020 spread to every
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
continent including Antarctica. The coronavirus, SARS-CoV-2, has been identified as the …
Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort
N Néant, G Lingas, Q Le Hingrat… - Proceedings of the …, 2021 - National Acad Sciences
The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viral kinetics in hospitalized patients and its association with mortality is unknown. We …
viral kinetics in hospitalized patients and its association with mortality is unknown. We …
Natural history of COVID-19 and therapeutic options
P Gautret, M Million, PA Jarrot… - Expert review of …, 2020 - Taylor & Francis
Introduction: COVID-19 presents benign forms in young patients who frequently present with
anosmia. Infants are rarely infected, while severe forms occur in patients over 65 years of …
anosmia. Infants are rarely infected, while severe forms occur in patients over 65 years of …
Structures of the SARS‐CoV‐2 nucleocapsid and their perspectives for drug design
Y Peng, N Du, Y Lei, S Dorje, J Qi, T Luo, GF Gao… - The EMBO …, 2020 - embopress.org
Abstract COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …