Inflammation is an essential immune response of the host against infections but is often over-
activated, leading to a variety of disorders. Autophagy, a conserved degradation pathway …

Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

Since the beginning of the COVID-19 pandemic, large in silico screening studies and
numerous in vitro studies have assessed the antiviral activity of various drugs on SARS-CoV …

Objectives: Severe acute respiratory syndrome coronavirus 2 cell entry depends on
angiotensin-converting enzyme 2 and transmembrane serine protease 2 and is blocked in …

While vaccination campaigns are ongoing worldwide, there is still a tremendous medical
need for efficient antivirals against SARS-CoV-2 infection. Among several drug candidates …

Within only one year after the first detection of severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), nearly 100 million infections were reported in the human …

Azithromycin has become famous in the last two years, not for its main antimicrobial effect,
but for its potential use as a therapeutic agent for COVID-19 infection. Initially, there were …

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a
mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques …

Objectives We evaluated the clinical, virological and safety outcomes of lopinavir/ritonavir,
lopinavir/ritonavir–interferon (IFN)-β-1a, hydroxychloroquine or remdesivir in comparison to …

Background QTc interval monitoring, for the prevention of drug-induced arrhythmias is
necessary, especially in the context of coronavirus disease 2019 (COVID-19). For the …