[HTML][HTML] Microglial implications in SARS-CoV-2 infection and COVID-19: Lessons from viral RNA neurotropism and possible relevance to Parkinson's disease

IO Awogbindin, B Ben-Azu, BA Olusola… - Frontiers in Cellular …, 2021 - frontiersin.org
Since December 2019, humankind has been experiencing a ravaging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, the second coronavirus …

[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes

D Dutta, J Liu, H Xiong - International journal of physiology …, 2022 - ncbi.nlm.nih.gov
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …

[HTML][HTML] Potential benefits of ginseng against COVID-19 by targeting inflammasomes

YS Yi - Journal of Ginseng Research, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that
causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper …

[HTML][HTML] Neuroinflammation in neurodegeneration via microbial infections

VTA Tran, LP Lee, H Cho - Frontiers in Immunology, 2022 - frontiersin.org
Recent epidemiological studies show a noticeable correlation between chronic microbial
infections and neurological disorders. However, the underlying mechanisms are still not …

[HTML][HTML] Activation of TLR4 by viral glycoproteins: A double-edged sword?

EA Halajian, EV LeBlanc, K Gee… - Frontiers in Microbiology, 2022 - frontiersin.org
Recognition of viral infection by pattern recognition receptors is paramount for a successful
immune response to viral infection. However, an unbalanced proinflammatory response can …

[HTML][HTML] Mitogen activated protein kinase (MAPK) activation, p53, and autophagy inhibition characterize the severe acute respiratory syndrome coronavirus 2 (SARS …

AM Kyriakopoulos, G Nigh, PA McCullough, S Seneff - Cureus, 2022 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and
prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions …

[HTML][HTML] Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

M Wang, F Yu, W Chang, Y Zhang, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a contagious respiratory
virus that is the cause of the coronavirus disease 2019 (COVID-19) pandemic which has …

Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study

LA Cysique, D Jakabek, SG Bracken, Y Allen-Davidian… - Medrxiv, 2022 - medrxiv.org
Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly
understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients …

Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …

MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …

Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern

SD Tyrkalska, A Martínez-López, AB Arroyo… - Science …, 2022 - science.org
The coronavirus disease 2019 (COVID-19) pandemic turned the whole world upside down
in a short time. One of the main challenges faced has been to understand COVID-19 …