Potential convergence of olfactory dysfunction in Parkinson's disease and COVID-19: The role of neuroinflammation

H Li, J Qian, Y Wang, J Wang, X Mi, L Qu… - Ageing Research …, 2024 - Elsevier
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects 7-10 million
individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and …

SARS-CoV-2 and multiple sclerosis: potential for disease exacerbation

M MacDougall, J El-Hajj Sleiman… - Frontiers in …, 2022 - frontiersin.org
While the respiratory tract is the primary route of entry for SARS-CoV-2, evidence shows that
the virus also impacts the central nervous system. Intriguingly, case reports have …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …

The viral hypothesis in Alzheimer's disease: SARS-CoV-2 on the cusp

N Liu, X Jiang, H Li - Frontiers in aging neuroscience, 2023 - frontiersin.org
Increasing evidence highlights that infection with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has long-term effects on cognitive function, which may cause …

Flipping the GPCR switch: Structure-based development of selective cannabinoid receptor 2 inverse agonists

M Kosar, RC Sarott, DA Sykes, AEG Viray… - ACS Central …, 2024 - ACS Publications
We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands
with a tailored functional response. The present study discloses the structure-based design …

SARS-CoV-2 Spike protein alters microglial purinergic signaling

VS Alves, SACS Santos, R Leite-Aguiar… - Frontiers in …, 2023 - frontiersin.org
Despite long-term sequelae of COVID-19 are emerging as a substantial public health
concern, the mechanism underlying these processes still unclear. Evidence demonstrates …

Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

R Dey, B Bishayi - Cellular and Molecular Neurobiology, 2024 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is primarily a respiratory disease causing a
worldwide pandemic in the year of 2019. SARS‐CoV‐2 is an enveloped, positive-stranded …

Systems analysis of innate and adaptive immunity in Long COVID

MJ Peluso, M Abdel-Mohsen, TJ Henrich… - Seminars in …, 2024 - Elsevier
Since the onset of the COVID-19 pandemic, significant progress has been made in
developing effective preventive and therapeutic strategies against severe acute SARS-CoV …

SARS-CoV-2 may trigger inflammasome and pyroptosis in the central nervous system: a mechanistic view of neurotropism

A Sepehrinezhad, A Gorji, S Sahab Negah - Inflammopharmacology, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the central
nervous system and cause several neurological manifestations. Data from cerebrospinal …

Carbon dioxide and MAPK signalling: towards therapy for inflammation

H Gałgańska, W Jarmuszkiewicz… - Cell Communication and …, 2023 - Springer
Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …