Increased Serum MMP-9 in Long-COVID May Reflect Activation of Microglia by SARS-CoV-2 Spike Protein

D Kempuraj, I Tsilioni, KK Aenlle, NG Klimas… - 2024 - researchsquare.com
Long-COVID is a major health concern because many patients develop chronic
neuropsychiatric symptoms, but the precise pathogenesis is unknown. Matrix …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome inmice

FLF Dantas, GG Fernandes, EG Gutman, EVD Lima… - 2023 - arca.fiocruz.br
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

MAPK Activation, P53 and Autophagy Inhibition Characterize the SARS-CoV-2 Spike Protein Induced Neurotoxicity

A Kyriakopoulos, G Nigh, PA McCullough… - Authorea …, 2022 - essopenarchive.org
The SARS-CoV-2 spike protein and prions use common pathogenic pathways to induce
toxicity in neurons. Infectious prions activate the p38 mitogen activated protein kinase …

Neuroprotection by skimmianine in lipopolysaccharide-activated BV-2 microglia

FA Ogunrinade, VU Iwuanyanwu, SD Sarker… - Molecules, 2023 - mdpi.com
Skimmianine is a furoquinoline alkaloid which is found in the Zanthoxylum genus and also
in other plants of the Rutaceae family. This study evaluated the effects of skimmianine on the …

[HTML][HTML] Long-term immune protection against SARS-CoV-2 escape variants upon a single vaccination with murine cytomegalovirus expressing the spike protein

Y Kim, H Jacobsen, B Fuerholzner, K Eschke… - 2022 - europepmc.org
Vaccines are central to controlling the coronavirus disease 2019 (COVID-19) pandemic but
the durability of protection is limited for currently approved COVID-19 vaccines. Further, the …

[PDF][PDF] Ability of a Clinical Stage LMW-DS Drug to Inhibit Coronavirus Infection of Cells and Suppress Cytokine Secretion from Human Microglia

A Logan, M Mazzon, J Cowley… - Journal of …, 2023 - research.birmingham.ac.uk
Most coronaviruses infect animals including bats, birds and mammals, which act as hosts
and reservoirs for the viruses, but the viruses can sometimes move host species and infect …

Evolution of targets at the host-pathogen interface

C Beaudoin - 2024 - repository.cam.ac.uk
Using comparative genomics, I investigate the protein-coding potential of globally-
distributed Mtb strains. Previous reports had suggested that the pan-genome (or all unique …

Evolution of Clinical, Biochemical and Microbiome Biomarkers of Conversion to Parkinson Disease in Glucocerebrosidase Mutation Carriers: Insights into Aetiology …

E Menozzi - 2024 - discovery.ucl.ac.uk
The penetrance of heterozygous variants in GBA1, the commonest genetic risk factor for
Parkinson disease (PD), is incomplete (10%-30%), but the reasons underlying this …

A clinical stage LMW-DS drug inhibits cell infection by coronaviruses and modulates reactive cytokine release from microglia

A Logan, M Mazzon, L Bruce, NM Barnes - bioRxiv, 2022 - biorxiv.org
Most coronaviruses infect animals including bats, birds and mammals, which act as hosts
and reservoirs for the viruses, but the viruses can sometimes move host species and infect …

The picture theory of seven pathways associated with COVID-19 in the real world

J hoon Lee, C Sergi, RE Kast, BA Kanwar… - 2024 - researchsquare.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated
diseases. Interactions between the host and virus govern induction, resulting in multiorgan …