To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in
the face of adverse environmental conditions or radical restructuring of the proteome during …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors.
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …

Vision impairment has devastating consequences for the quality of human life. The cells and
tissues associated with the visual process must function throughout one's life span and …

Aging involves progressive physiological and metabolic reprogramming to adapt to gradual
deterioration of organs and functions. This includes mechanisms of defense against pre …

Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates
a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated …

The proteostasis network (PN) regulates protein synthesis, folding, and degradation and is
critical for the health and function of all cells. The PN has been extensively studied in the …

Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine
dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental …

Women are born with all of their oocytes. The oocyte proteome must be maintained with
minimal damage throughout the woman's reproductive life, and hence for decades. Here we …

Tissue integrity is sensitive to temperature, tension, age, and is sustained throughout life by
adaptive cell-autonomous or extrinsic mechanisms. Safeguarding the remarkably-complex …