Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …

Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …

The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

Alterations in DNAs could not reveal what happened in proteins. The accumulated
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …

Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …

Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …

The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …