Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Vascular cognitive impairment and dementia (VCID) is a major heterogeneous brain
disease caused by multiple factors, and it is the second most common type of dementia in …

Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …

Parkinson's disease (PD) is conventionally described as an α-synuclein aggregation
disorder, defined by Lewy bodies and neurites, and mutations in leucine-rich repeat kinase …

Background Differentiating progressive supranuclear palsy‐parkinsonism (PSP‐P) from
Parkinson's disease (PD) is clinically challenging. Objective This study aimed to develop an …

Objectives To evaluate the difference of tau burden between patients with progressive
supranuclear palsy (PSP) and healthy controls (HCs) or other neurodegenerative diseases …

Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and
is responsible for both motor and cognitive symptoms. Recently, it has been suggested that …

The most common clinical phenotype of progressive supranuclear palsy is Richardson
syndrome, characterized by levodopa unresponsive symmetric parkinsonism, with a vertical …

Background To date, studies on positron emission tomography (PET) with 18F‐
fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP …