To date, non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease,
affecting up to 70% of patients with diabetes. Currently, there are no specific drugs available …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Tirzepatide is a new molecule capable of controlling glucose blood levels by combining the
dual agonism of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like …

Abstract Purpose of Review Chronic kidney disease (CKD) is a common condition and a
major cause of morbidity and mortality in adults, but children and adolescents are also at risk …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

Purpose A systematic review and meta-analysis was conducted to synthesize the available
data from clinical trials and assess the safety issues of tirzepatide (pancreatitis and …

Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide (GIP)/glucagon-
like peptide-1 (GLP-1) receptor agonist (GIP/GLP-1 RA) improves glycemic control. Besides …

Abstract Purpose of the Review This review summarizes the new developments in
polyagonist pharmacotherapy for type 2 diabetes. Recent Findings Several dual-and triple …

Introduction Type 2 diabetes mellitus (T2DM) is one of the leading causes of morbidity and
mortality. Peptide-based multi-targeting agonists represent a new paradigm in metabolic …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors, with
many GPCRs having crucial roles in endocrinology and metabolism. Cryogenic electron …