Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy

KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022 - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Pickering emulsion catalysis: interfacial chemistry, catalyst design, challenges, and perspectives

L Ni, C Yu, Q Wei, D Liu, J Qiu - Angewandte Chemie, 2022 - Wiley Online Library
Pickering emulsions are particle‐stabilized surfactant‐free dispersions composed of two
immiscible liquid phases, and emerge as attractive catalysis platform to surpass traditional …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine

S Pan, A Ding, Y Li, Y Sun, Y Zhan, Z Ye… - Chemical Society …, 2023 - pubs.rsc.org
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Nanoparticulation of prodrug into medicines for cancer therapy

Y Zhang, H Cui, R Zhang, H Zhang… - Advanced …, 2021 - Wiley Online Library
This article provides a broad spectrum about the nanoprodrug fabrication advances co‐
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …

Recent advances in self-immolative linkers and their applications in polymeric reporting systems

AG Gavriel, MR Sambrook, AT Russell, W Hayes - Polymer Chemistry, 2022 - pubs.rsc.org
Interest in self-immolative chemistry has grown over the past decade with more research
groups harnessing the versatility to control the release of a compound from a larger …

Clickable polysaccharides for biomedical applications: a comprehensive review

MK Yazdi, SM Sajadi, F Seidi, N Rabiee… - Progress in polymer …, 2022 - Elsevier
Recent advances in materials science and engineering highlight the importance of
designing sophisticated biomaterials with well-defined architectures and tunable properties …

Introduction to antibody-drug conjugates

MC Pettinato - Antibodies, 2021 - mdpi.com
Antibody-drug conjugates (ADCs) are innovative biopharmaceutical products in which a
monoclonal antibody is linked to a small molecule drug with a stable linker. Most of the …