The essential event in picornavirus entry is the delivery of the RNA genome to the cytoplasm
of a target cell, where replication occurs. In the past several years progress has been made …

Conformational activation increases the affinity of integrins to their ligands. On ligand
binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the …

US7358054B2 - Antibodies to VLA-1 - Google Patents US7358054B2 - Antibodies to VLA-1 -
Google Patents Antibodies to VLA-1 Download PDF Info Publication number US7358054B2 …

Viruses that propagate within vertebrate hosts have adapted many strategies to infect host
cells. One of the first steps in a viral infection is the binding of the virus to cell surface …

Background: The integrin family of cell-surface receptors mediate cell adhesion through
interactions with the extracellular matrix or other cell-surface receptors. The α chain of some …

Integrins are cell surface receptors for several microbial pathogens including echovirus 1
(EV1), a picornavirus. Cryo-electron microscopy revealed that the functional domain (α 2 I) of …

The α 1 β 1 and α 2 β 1 integrins are cell surface collagen receptors. Cells expressing the α
1 β 1 integrin preferentially adhere to collagen IV, whereas cells expressing the α 2 β 1 …

The integrin α9β1 is expressed on epithelial cells, smooth muscle cells, skeletal muscle, and
neutrophils and recognizes at least three distinct ligands: vascular cell adhesion molecule 1 …

Two pilus receptors are identified for the pathogenic Neisseria, CD46 and complement
receptor 3. An intimate association between the asialoglycoprotein receptor and gonococcal …

Rhodocetin is a snake venom protein that binds to α2β1 integrin, inhibiting its interaction
with its endogenous ligand collagen. We have determined the mechanism by which …