Echoviruses have been implicated in multiple human disease syndromes, including aseptic
meningitis, paralysis, and heart disease, but no animal model is available for studying the …

Integrin α2β1 is a major receptor required for activation and adhesion of platelets, through
the specific recognition of collagen by the α2-I domain (α2-I), which binds fibrillar collagen …

Abstract In humans, an~ 200-residue “inserted” I domain, a von Willebrand factor A domain
(vWFA), buds out from the β-propeller domain in 9 of 18 integrin α subunits. The vWFA …

Integrin α 1 β 1 and α 2 β 1 are the major cellular receptors for collagen, and collagens bind
to these integrins at the inserted I-domain in their α subunit. We have previously shown that …

Rotaviruses utilize integrins during virus-cell interactions that lead to infection. Cell binding
and infection by simian rotavirus SA11 were inhibited by antibodies (Abs) to the inserted (I) …

For several virus families, significant progress has been made in understanding the
molecular events associated with viral cell entry. These events include stable attachment of …

Background Virus‐receptor binding is an essential step in every virus infectious process.
Many viruses employ more than one receptor molecule or even receptor complexes for …

Targeting of viral vectors to specific cells has received an increasing interest in the area of
therapeutic gene transfer. However, specific targeting to tumors, especially to tumor …

To efficiently enter cells, viruses utilize different endocytic pathways. In this thesis, the
regulators and entry routes utilized by a human pathogen, echovirus 1 (EV1), as well as an …

BACKGROUND 0004 Integrins are cell-bound molecules that aid cell-to cell interactions by
providing binding sites for other cells. The integrins are receptors that recognize Specific …