Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Machine learning approaches in microbiome research: challenges and best practices

G Papoutsoglou, S Tarazona, MB Lopes… - Frontiers in …, 2023 - frontiersin.org
Microbiome data predictive analysis within a machine learning (ML) workflow presents
numerous domain-specific challenges involving preprocessing, feature selection, predictive …

Gut microbiota in colorectal cancer: biological role and therapeutic opportunities

H Pandey, DWT Tang, SH Wong, D Lal - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Microbiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development

RY Tito, S Verbandt, M Aguirre Vazquez, L Lahti… - Nature medicine, 2024 - nature.com
Despite substantial progress in cancer microbiome research, recognized confounders and
advances in absolute microbiome quantification remain underused; this raises concerns …

Intestinal bacteria and colorectal cancer: etiology and treatment

MW Dougherty, C Jobin - Gut Microbes, 2023 - Taylor & Francis
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …

Colon cancer: from epidemiology to prevention

K Katsaounou, E Nicolaou, P Vogazianos, C Brown… - Metabolites, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …

Pathogens and carcinogenesis: a review

MNA Hatta, EA Mohamad Hanif, SF Chin, H Neoh - Biology, 2021 - mdpi.com
Simple Summary An increasing number of cancer cases has been reported throughout the
years. Most cancers are linked to unhealthy lifestyles and genetic inheritance. Nevertheless …

Dysbiotic change in gastric microbiome and its functional implication in gastric carcinogenesis

JY Park, H Seo, CS Kang, TS Shin, JW Kim, JM Park… - Scientific reports, 2022 - nature.com
Although there is a growing interest in the role of gastric microbiome on the development of
gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the …

Male‐Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development

L Wang, YX Tu, L Chen, Y Zhang, XL Pan… - Advanced …, 2023 - Wiley Online Library
Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than
women. This study aims to explain the potential causes of such sexual dimorphism in CRC …

[HTML][HTML] The role of microbiota in gastrointestinal cancer and cancer treatment: chance or curse?

A Smet, J Kupcinskas, A Link, GL Hold… - Cellular and Molecular …, 2022 - Elsevier
The gastrointestinal (GI) tract is home to a complex and dynamic community of
microorganisms, comprising bacteria, archaea, viruses, yeast, and fungi. It is widely …