Polycomb group (PcG) proteins comprise evolutionary conserved factors with essential
functions for embryonic development and adult stem cells. PcG proteins constitute two main …

5-Fluorouracil (5-FU) is an important chemotherapeutic agent for nasopharyngeal
carcinoma (NPC). However, drug resistance may occur after several cycles of 5-FU-based …

Polycomb group proteins (PcGs) are transcriptional repressors involved in physiological
processes whereas PcG deregulation might result in oncogenesis. MYC oncogene is able to …

The proto-oncogene c-Myc is vital for vascular development and promotes tumor
angiogenesis, but the mechanisms by which it controls blood vessel growth remain unclear …

Endometrial cancer (EC) is the third leading gynecological malignancy, and its treatment
remains challenging. B cell-specific Moloney murine leukemia virus integration site-1 (BMI1) …

Polycomb group (PcG) protein BMI1 is an important regulator of oncogenic phenotype and is
often overexpressed in several human malignancies including breast cancer. Aberrant …

MicroRNAs (miRNAs) are known to function as oncomiRs or tumor suppressors and are
important noncoding RNA regulators of oncogenesis. The miR-200c/141 locus on …

N6‐methyladenosine (m6A) modification plays a pivotal role in cell fate determination.
Previous studies show that eliminating m6A using Mb1-Cre dramatically impairs B cell …

Chronic kidney disease (CKD), commonly fostering nonrenal complications, themselves
more life threatening than renal pathology, remains enigmatic. Despite more than a century …

The transcription factor runt-related transcription factor 1 (Runx1) is essential for the
establishment of definitive hematopoiesis during embryonic development. In adult blood …