Psychosis Psychosis is a syndrome embedded in several disorders, including schizophrenia
and bipolar disorder with psychotic features. Dopamine and glutamate are implicated in the …

A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …

Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …

Single-cell RNA sequencing (scRNA-seq) data allows to create cell type specific
transcriptome profiles. Such profiles can be aligned with genome-wide association studies …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …