Epigenetic biomarkers for disease susceptibility and preventative medicine

MK Skinner - Cell metabolism, 2024 - cell.com
The development of molecular biomarkers for disease makes it possible for preventative
medicine approaches to be considered. Therefore, therapeutics, treatments, or clinical …

Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus

J Martínez-Pinna, R Sempere-Navarro… - American Journal …, 2023 - journals.physiology.org
Plastic pollution breaks a planetary boundary threatening wildlife and humans through its
physical and chemical effects. Of the latter, the release of endocrine disrupting chemicals …

[HTML][HTML] Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population

C Vasseur, L Serra, S El Balkhi, G Lefort… - Ecotoxicology and …, 2024 - Elsevier
Environmental exposure to endocrine disruptors, such as pesticides, could contribute to a
decline of human fertility. Glyphosate (GLY) is the main component of Glyphosate Based …

[HTML][HTML] Systemic epigenome-wide association study of elk treponeme-associated hoof disease

MA Wild, KR Taylor, EE Nilsson, D Beck, MK Skinner - Scientific reports, 2023 - nature.com
Treponeme-associated hoof disease (TAHD) is an emerging disease of elk (Cervus
canadensis) in the US Pacific West. Because environmental epigenetics is the primary …

[HTML][HTML] The consequences of assisted reproduction technologies on the offspring health throughout life: A placental contribution

M Schroeder, G Badini, AN Sferruzzi-Perri… - Frontiers in cell and …, 2022 - frontiersin.org
The use of assisted reproductive technologies (ART) worldwide has led to the conception
and birth of over 8 million babies since being implemented in 1978. ART use is currently on …

Concern over differences between experimental design and data analyses in Jones et al.

CV Vorhees - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Jones et al.(1) exposed C57/BL mice to 0, 0.0075, 0.015, or 0.3% aspartame in drinking
water in a 4-group× 2-sex experimental design and report reduced open-field center time …

[HTML][HTML] Impact of fetal exposure to endocrine disrupting chemical mixtures on FOXA3 gene and protein expression in adult rat testes

C Walker, A Boisvert, P Malusare, M Culty - International journal of …, 2023 - mdpi.com
Perinatal exposure to endocrine disrupting chemicals (EDCs) has been shown to affect male
reproductive functions. However, the effects on male reproduction of exposure to EDC …

Combined threats of climate change and contaminant exposure through the lens of bioenergetics

ML Grunst, AS Grunst, D Grémillet… - Global Change …, 2023 - Wiley Online Library
Organisms face energetic challenges of climate change in combination with suites of natural
and anthropogenic stressors. In particular, chemical contaminant exposure has neurotoxic …

[HTML][HTML] A systematic scientometric review of paternal inheritance of acquired metabolic traits

L Crisóstomo, PF Oliveira, MG Alves - BMC biology, 2023 - Springer
Background The concept of the inheritance of acquired traits, a foundational principle of
Lamarck's evolutionary theory, has garnered renewed attention in recent years. Evidence for …

[PDF][PDF] Examination of generational impacts of adolescent chemotherapy: Ifosfamide and potential for epigenetic transgenerational inheritance

RP Thompson, D Beck, E Nilsson, MB Maamar… - Iscience, 2022 - cell.com
The current study was designed to use a rodent model to determine if exposure to the
chemotherapy drug ifosfamide during puberty can induce altered phenotypes and disease …