[HTML][HTML] Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
JF Chen, SW Wu, ZM Shi, B Hu - Chinese Medicine, 2023 - Springer
Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …
and its development involves abnormalities in multiple signaling pathways. Surgery …
[HTML][HTML] Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway
M Tufail, JJ Hu, J Liang, CY He, WD Wan… - Journal of Translational …, 2024 - Springer
Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/AKT signaling pathway
MR Khezri, S Mohammadipanah… - Phytotherapy …, 2024 - Wiley Online Library
Abstract The phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway plays a central
role in cell growth and survival and is disturbed in various pathologies. The PI3K is a kinase …
role in cell growth and survival and is disturbed in various pathologies. The PI3K is a kinase …
[HTML][HTML] Exploration of anti‑osteosarcoma activity of asiatic acid based on network pharmacology and in vitro experiments
H Pang, H Wu, Z Zhan, T Wu, M Xiang… - Oncology …, 2024 - spandidos-publications.com
Osteosarcomas are malignant bone tumors that typically originate in the epiphyses of the
long bones of the extremities in adolescents. Asiatic acid has been reported to possess anti …
long bones of the extremities in adolescents. Asiatic acid has been reported to possess anti …
[HTML][HTML] Nonsense-mediated mRNA decay as a mediator of tumorigenesis
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved and well-
characterized biological mechanism that ensures the fidelity and regulation of gene …
characterized biological mechanism that ensures the fidelity and regulation of gene …
Toxic effects of cadmium exposure on intestinal histology, oxidative stress, microbial community, and transcriptome change in the mud crab (Scylla paramamosain)
CH Cheng, HL Ma, GX Liu, SG Fan, YQ Deng, JJ Jiang… - Chemosphere, 2023 - Elsevier
Cadmium is one of hazardous pollutants that has a great threat to aquatic organisms and
ecosystems. The intestine plays important roles in barrier function and immunity to defend …
ecosystems. The intestine plays important roles in barrier function and immunity to defend …
Simultaneous and Sensitive Sensing of Intracellular MicroRNA and mRNA for the Detection of the PI3K/AKT Signaling Pathway in Live Cells
D Li, Y Liu, Y Li, Y Xiang, R Yuan - Analytical Chemistry, 2024 - ACS Publications
Simultaneous detection of the concentration variations of microRNA-221 (miRNA-221) and
PTEN mRNA molecules in the PI3K/AKT signaling pathway is of significance to elucidate …
PTEN mRNA molecules in the PI3K/AKT signaling pathway is of significance to elucidate …
Natural products and derivatives in renal, urothelial and testicular cancers: targeting signaling pathways and therapeutic potential
Background: Natural products have demonstrated significant potential in cancer drug
discovery, particularly in renal cancer (RCa), urothelial carcinoma (UC), and testicular …
discovery, particularly in renal cancer (RCa), urothelial carcinoma (UC), and testicular …
Ropivacaine represses the ovarian cancer cell stemness and facilitates cell ferroptosis through inactivating the PI3K/AKT signaling pathway
Y Lu, J Mao, Y Xu, H Pan, Y Wang… - Human & experimental …, 2022 - journals.sagepub.com
Purpose Ovarian cancer is a malignant tumor in women all over the world. Ropivacaine is
identified as a potential drug for the treatment of malignant tumors, but the role and …
identified as a potential drug for the treatment of malignant tumors, but the role and …
Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines
M Lukoseviciute, S Holzhauser… - Oncology …, 2023 - spandidos-publications.com
Neuroblastoma (NB), the most frequent solid extracranial tumor in children, is not always
cured by current aggressive therapies that have notable adverse effects; therefore, novel …
cured by current aggressive therapies that have notable adverse effects; therefore, novel …