Despite major therapeutic advances, most mature B-cell malignancies remain incurable.
Compelling evidence suggests that crosstalk with accessory stromal cells in specialized …

A defining characteristic of the immune system is the constant movement of many of its
constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph …

Despite the immense public health successes of immunization over the past century,
effective vaccines are still lacking for globally important pathogens such as human …

The dynamics of when and where CD4+ T cells provide help for CD8+ T cell priming and
which dendritic cells (DCs) activate CD4+ T cells in vivo after localized infection are poorly …

For subunit vaccines, adjuvants play a key role in shaping immunological memory.
Nanoparticle (NP) delivery systems for antigens and/or molecular danger signals are …

B cells constitute an essential line of defense from pathogenic infections through the
generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although …

The generation of high-affinity antibodies depends on the ability of B cells to extract antigens
from the surfaces of antigen-presenting cells. B cells that express high-affinity B cell …

Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor
patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 …

Therapeutic delivery selectively to lymph nodes has the potential to address a variety of
unmet clinical needs. However, owing to the unique structure of the lymphatics and the size …

The continued threat of emerging, highly lethal infectious pathogens such as Middle East
respiratory syndrome coronavirus (MERS‐CoV) calls for the development of novel vaccine …