The lymphatic network that transports interstitial fluid and antigens to lymph nodes
constitutes a conduit system that can be hijacked by invading pathogens to achieve systemic …

Here we investigate the dynamics of the hepatic intravascular immune response to a
pathogen relevant to invariant natural killer T cells (i NKT cells). Immobilized Kupffer cells …

Although the signals that control neutrophil migration from the blood to sites of infection have
been well characterized, little is known about their migration patterns within lymph nodes or …

Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its
native form. The B cell receptor used in recognition can also be secreted to bind to antigens …

Immune responses to persistent viral infections and cancer often fail because of intense
regulation of antigen-specific T cells—a process referred to as immune exhaustion. The …

Lymph nodes (LNs) capture microorganisms that breach the body's external barriers and
enter draining lymphatics, limiting the systemic spread of pathogens. Recent work has …

Resident memory CD8 T cells (T RM) are a nonrecirculating subset positioned in
nonlymphoid tissues to provide early responses to reinfection. Although T RM are …

Lymphatic vessels are well known to participate in the immune response by providing the
structural and functional support for the delivery of antigens and antigen presenting cells to …

Germinal centers (GCs) are specialized microenvironments formed after infection where
activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent …

Protection from yearly recurring, highly acute infections with a pathogen that rapidly and
continuously evades previously induced protective neutralizing Abs, as seen during …