Extracellular vesicles as a next-generation drug delivery platform

IK Herrmann, MJA Wood, G Fuhrmann - Nature nanotechnology, 2021 - nature.com
Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of
life. There is compelling evidence that extracellular vesicles are involved in major (patho) …

Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles

KW Witwer, DCI Goberdhan, L O'Driscoll… - Journal of …, 2021 - Wiley Online Library
The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field‐
consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The …

Exosome-based vaccines: history, current state, and clinical trials

P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virus

F Cocozza, N Névo, E Piovesana… - Journal of …, 2020 - Wiley Online Library
SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to the surface receptor
ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we …

Biological features of extracellular vesicles and challenges

Y Zeng, Y Qiu, W Jiang, J Shen, X Yao, X He… - Frontiers in Cell and …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are vesicles with a lipid bilayer membrane on the outside, which
are widely found in various body fluids and contain biological macromolecules such as …

Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Mesenchymal stem cell (MSC)-derived exosomes as a cell-free therapy for patients Infected with COVID-19: Real opportunities and range of promises

L Rezakhani, AF Kelishadrokhi… - Chemistry and physics …, 2021 - Elsevier
There are no commercially available effective antiviral medications or vaccines to deal with
novel coronavirus disease (COVID-19). Hence there is a substantial unmet medical need for …