Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
[HTML][HTML] Pharmaco-immunomodulatory therapy in COVID-19
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …
[HTML][HTML] IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
[HTML][HTML] Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …
Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes
A subset of patients with severe COVID-19 develop profound inflammation and multi-organ
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …
dysfunction consistent with a “Cytokine Storm Syndrome”(CSS). In this review we compare …
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications
N Banu, SS Panikar, LR Leal, AR Leal - Life sciences, 2020 - Elsevier
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …
scientific community has joined forces to develop effective treatment strategies. The …
[HTML][HTML] COVID 19: a clue from innate immunity
D Birra, M Benucci, L Landolfi, A Merchionda, G Loi… - Immunologic …, 2020 - Springer
The recent COVID-19 pandemic has had a significant impact on our lives and has rapidly
expanded to reach more than 4 million cases worldwide by May 2020. These cases are …
expanded to reach more than 4 million cases worldwide by May 2020. These cases are …
Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19
R Cauchois, M Koubi, D Delarbre… - Proceedings of the …, 2020 - National Acad Sciences
Around the tenth day after diagnosis,∼ 20% of patients with coronavirus disease 2019
(COVID-19)− associated pneumonia evolve toward severe oxygen dependence (stage 2b) …
(COVID-19)− associated pneumonia evolve toward severe oxygen dependence (stage 2b) …
Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID‐19—Mechanisms and Therapeutic Targets
The outbreak of the COVID‐19 pandemic represents an ongoing healthcare emergency
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …
Weathering the cytokine storm in COVID-19: therapeutic implications
G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently
emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID …
emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID …