Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

The translation of the growing increase of findings emerging from basic nutritional science
into meaningful and clinically relevant dietary advices represents nowadays one of the main …

Severe obesity is a rapidly growing global health threat. Although often attributed to
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …

In the past decade, precision genomics based medicine has emerged to provide tailored
and effective healthcare for patients depending upon their genetic features. Genome Wide …

It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …

Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Recent studies have begun to uncover the genetic architecture of educational attainment.
We build on this work using genome-wide data from siblings in the National Longitudinal …

Objectives To investigate associations between a high genetic disease risk and disease
severity in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE (n …

Except in rare cases, obesity tends to be a consequence of both an unhealthy lifestyle and a
genetic susceptibility to gain weight. With more than 200 common genetic variants identified …

Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …