Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal
dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a …

IgE-dependent mast cell activation is a major effector mechanism underlying the pathology
associated with allergic disorders. The most dramatic of these IgE-associated disorders is …

The survival of helminths in the host over long periods of time is the result of a process of
adaptation or dynamic co-evolution between the host and the parasite. However, infection …

Heligmosomoides polygyrus is a natural intestinal parasite of mice, which offers an excellent
model of the immunology of gastrointestinal helminth infections of humans and livestock. It is …

Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals
and humans, with over a billion of the world's population infected with at least one species …

Similar T helper (Th) 2-type immune responses are generated against different helminth
parasites, but the mechanisms that initiate Th2 immunity, and the specific immune …

Infection with soil-transmitted gastrointestinal parasites, such as Trichuris trichiura, affects
more than a billion people worldwide, causing significant morbidity and health problems …

Helminth parasites are a large group of multicellular organisms that affect vast numbers of
humans and are a major cause of disease. Several relevant experimental murine models …

Two models are proposed to explain Notch function during helper T (Th) cell differentiation.
One argues that Notch instructs one Th cell fate over the other, whereas the other posits that …

Gastrointestinal helminths infect over 1 billion people worldwide. Although rarely causing
death, such diseases are associated with high levels of morbidity and furthermore bear a …