More than a decade of genetic research on the Denisovans

S Peyrégne, V Slon, J Kelso - Nature Reviews Genetics, 2024 - nature.com
Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …

Something old, something borrowed: admixture and adaptation in human evolution

M Dannemann, F Racimo - Current opinion in genetics & development, 2018 - Elsevier
The sequencing of ancient DNA from archaic humans—Neanderthals and Denisovans—has
revealed that modern and archaic humans interbred at least twice during the Pleistocene …

[HTML][HTML] Evidence that RNA viruses drove adaptive introgression between Neanderthals and modern humans

D Enard, DA Petrov - Cell, 2018 - cell.com
Neanderthals and modern humans interbred at least twice in the past 100,000 years. While
there is evidence that most introgressed DNA segments from Neanderthals to modern …

The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans

X Zhang, KE Witt, MM Bañuelos, A Ko… - Proceedings of the …, 2021 - National Acad Sciences
Recent studies suggest that admixture with archaic hominins played an important role in
facilitating biological adaptations to new environments. For example, interbreeding with …

[HTML][HTML] Evolutionary selection and constraint on human knee chondrocyte regulation impacts osteoarthritis risk

D Richard, Z Liu, J Cao, AM Kiapour, J Willen… - Cell, 2020 - cell.com
During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …

A need for standardized reporting of introgression: Insights from studies across eukaryotes

AJ Dagilis, D Peede, JM Coughlan, GI Jofre… - Evolution …, 2022 - academic.oup.com
With the rise of affordable next-generation sequencing technology, introgression—or the
exchange of genetic materials between taxa—has become widely perceived to be a …

Hybridization in human evolution: Insights from other organisms

RR Ackermann, ML Arnold, MD Baiz… - … : Issues, News, and …, 2019 - Wiley Online Library
During the late Pleistocene, isolated lineages of hominins exchanged genes thus
influencing genomic variation in humans in both the past and present. However, the …

[HTML][HTML] Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde

I Hamid, KL Korunes, S Beleza, A Goldberg - Elife, 2021 - elifesciences.org
Humans have undergone large migrations over the past hundreds to thousands of years,
exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing …

[HTML][HTML] Fluctuating selection and the determinants of genetic variation

OL Johnson, R Tobler, JM Schmidt, CD Huber - Trends in Genetics, 2023 - cell.com
Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands
of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating …

Impact of historic migrations and evolutionary processes on human immunity

J Domínguez-Andrés, MG Netea - Trends in Immunology, 2019 - cell.com
The evolution of mankind has constantly been influenced by the pathogens encountered.
The various populations of modern humans that ventured out of Africa adapted to different …